Berbamine (CAS 478-61-5) Suppliers and Product Information

Berbamine is an alkaloid mainly extracted from plants of the Berberidaceae family, such as Berberis julianae, Berberis wilsonae, and Berberis poiretii. It belongs to the bisbenzylisoquinoline alkaloid class and has various pharmacological properties, including antihypertensive and skeletal muscle relaxant effects. Berbamine is primarily used in the prevention and treatment of neutropenia in cancer patients undergoing radiotherapy or chemotherapy, as well as in cases of benzene poisoning and drug-induced neutropenia.

Frequently Asked Questions about Berbamine

Q: What are the main uses of Berbamine?

A: Berbamine is primarily used for: - Prevention and treatment of neutropenia in cancer patients undergoing radiotherapy or chemotherapy - Treatment of neutropenia caused by benzene poisoning or drug-induced factors - As an antihypertensive agent - As a skeletal muscle relaxant

Q: How does Berbamine work in the body?

A: Berbamine works by: - Promoting hematopoietic function and stimulating myeloid proliferation - Enhancing the content of hematopoietic stem cells and granulocyte colony-stimulating factor (G-CSF) - Increasing the proliferation and differentiation of bone marrow hematopoietic stem cells and granule progenitor cells - Acting as a calcium ion blocker (dihydropyridine class) - Inhibiting NF-kB signaling in certain cancer cells

Q: Are there any potential anti-cancer properties of Berbamine?

A: Yes, preclinical studies have shown that Berbamine can inhibit the proliferation of various tumor cells, including: - Human high metastatic breast cancer cells (MDA-MB-231) - Non-small cell lung cancer cells (A549) - Liver cancer cells (SMMC772l and HepG2) - Multiple myeloma cells (KM3 and RPMl8226) - Chronic myeloid leukemia (CML) cells (KU812 and imatinib-resistant K562 cells)