Sibutramine: Chemical Properties, Uses, and Supplier Information

Chemical Properties	- Melting point: 191-192°C - Boiling point: 342.6°C at 25.0°C - Predicted density: 1.031 ± 0.06 g/cm³ - Predicted solubility: Slightly soluble in Chloroform, DMSO, and Ethyl Acetate - Form: Solid - pKa: 9.69 ± 0.50 - Predicted color: White to Off-White - Water Solubility: 2.9 mg/mL
Pharmacological Effects	- Centrally acting weight loss pill - Non-amphetamine appetite suppressant - Inhibits reuptake of norepinephrine, serotonin, and dopamine - Reduces appetite and increases sense of fullness - Accelerates body energy consumption - Mild antidepressant effect
Pharmacokinetics	- Oral bioavailability: 77% - Peak plasma concentration: 1-2 hours - Protein binding rate: 97% - Highest concentration in liver and kidney - Metabolized into two active metabolites: single nor-sibutramine and dual nor-sibutramine - Metabolite peak time: 3-4 hours - Half-life of parent drug: 1.1 hours - Half-life of metabolites: 14-16 hours

Frequently Asked Questions about Sibutramine

Q: What is Sibutramine used for?

A: Sibutramine is primarily used as a weight loss medication. It acts as an appetite suppressant and helps increase the sense of fullness, leading to reduced food intake and weight loss.

Q: How does Sibutramine work in the body?

A: Sibutramine works by inhibiting the reuptake of neurotransmitters such as norepinephrine, serotonin, and dopamine in the brain. This action helps reduce appetite, increase feelings of fullness, and boost energy expenditure, contributing to weight loss.

Q: What are the main chemical properties of Sibutramine?

A: Sibutramine is a solid compound with a melting point of 191-192°C and a boiling point of 342.6°C. It has a predicted density of 1.031 g/cm³ and is slightly soluble in chloroform, DMSO, and ethyl acetate. Its appearance is typically white to off-white.

Q: Are there any side effects associated with Sibutramine?

A: While the provided information doesn't specifically list side effects, it's important to note that all medications can have potential side effects. As Sibutramine affects neurotransmitters and has mild antidepressant effects, it may have both intended and unintended effects on the body. Always consult with a healthcare professional for complete information on side effects and safety.