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Leptomycin A (CAS 87081-36-5) Suppliers and Product Information

bob
API
2024-07-22 22:02:44
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Property	Information
Product Name	Leptomycin A
CAS Number	87081-36-5
Molecular Formula	C32H46O6
Molecular Weight	526.70
Description	Antifungal antibiotic, inhibitor of CRM1 (exportin 1)
Solubility	Soluble in ethanol and methanol
Storage	-20°C
Form	Methanol solution
Color	Colorless to light yellow

Leptomycin A is an antifungal antibiotic and inhibitor of CRM1 (exportin 1). It blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. It was originally identified as an antifungal agent and shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.

Frequently Asked Questions

2Leptomycin A (CAS 87081-36-5) Suppliers and Product Information

Q: What is the primary use of Leptomycin A?

A: Leptomycin A is primarily used as an antifungal antibiotic and as a research tool to study nuclear export processes. It inhibits CRM1 (exportin 1), which is involved in the nuclear export of proteins.

Q: How does Leptomycin A compare to Leptomycin B?

A: Leptomycin A is a methyl ***ogue of Leptomycin B and is a minor component of the leptomycin complex. While both inhibit nuclear transport, Leptomycin A is less potent than Leptomycin B in inhibiting Rev translocation, with IC50 values of 0.8 and 0.1 nM respectively after 7 hours.

Q: What is the source of Leptomycin A?

A: Leptomycin A is produced by selected Streptomyces species, which are a genus of bacteria.

Company Name	Contact Information	Product Details
Shaanxi Dideu Medichem Co., Ltd.	Tel: 86 029 81138252, 86 18789408387	Purity: 99%, Package: 1KG
TargetMol Chemicals Inc.	Tel: 1 781 999 5354	Purity: 98.00%, Package: 100 mg, 500 mg, Remarks: Reagent for laboratory use only
Shaanxi Dideu Medichem Co., Ltd.	Tel: 86 029 89586680, 86 18192503167	Purity: 99.9%, Package: 25kgs Drum, 200kgs Drum, Remarks: FDA GMP CEP Approved Manufacturer
Shanghai Minbiotech Co., Ltd.	Tel: 8617315815539	Purity: 99% (HPLC), Package: 1g, 1kg, 10kg
AFINE CHEMICALS LIMITED	Tel: 86 0571 85134551	Purity: 98%, Package: Standard or custom package, Remarks: Excellent quality and reliable supplier

This article was written by bob and published on 2024-07-22 22:02:44. Original article, reproduction is prohibited. The content is for entertainment purposes only and should not be taken as fact.
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