Thiostrepton (CAS 1393-48-2) Suppliers and Product Information

Thiostrepton is an antibiotic that inhibits bacterial protein synthesis. It acts by preventing the binding of GTP to the 50S ribosomal subunit and inhibits the function of elongation factor G (EF-G). Thiostrepton also has antitumor properties, inducing cell cycle arrest and apoptosis in cancer cells, particularly through inhibition of the transcription factor FOXM1.

In research, thiostrepton is used as a tool compound to study protein synthesis inhibition and as a potential anticancer agent. It has shown efficacy against various cancer types including breast cancer, leukemia, and liver cancer in preclinical studies.

Frequently Asked Questions about Thiostrepton

Q: What is the primary mechanism of action of thiostrepton?

A: Thiostrepton primarily inhibits bacterial protein synthesis by preventing the binding of GTP to the 50S ribosomal subunit and inhibiting the function of elongation factor G (EF-G). It also inhibits mRNA-tRNA translocation and the activity of initiation factor 2 (IF-2).

Q: Does thiostrepton have any anticancer properties?

A: Yes, thiostrepton has shown anticancer properties. It induces cell cycle arrest and apoptosis in cancer cells, particularly through the inhibition of the transcription factor FOXM1. This effect has been observed in various cancer types, including breast cancer, leukemia, and liver cancer.

Q: How should thiostrepton be stored?

A: Thiostrepton should be stored in a freezer at temperatures below -20°C. When in solution (e.g., in DMSO), it can be stored at -20°C for up to 1 week.