Property | Information |
---|---|
Product Name | Micafungin |
CAS Number | 235114-32-6 |
Molecular Formula | C56H71N9O23S |
Molecular Weight | 1270.28 |
Melting Point | 198°C (dec.) |
Appearance | White to Off-White Solid |
Solubility | Slightly soluble in DMSO, Very slightly soluble in Methanol |
Storage | Hygroscopic, store at -20°C freezer under inert atmosphere |
Micafungin is an echinocandin antifungal drug that inhibits the synthesis of β-1,3-glucan, an essential component of fungal cell walls. It is used for treating various fungal infections caused by Aspergillus and Candida species, including candidemia, acute disseminated candidiasis, Candida peritonitis, abscesses, and esophageal candidiasis. Micafungin has fungicidal activity against some Candida species and fungistatic activity against Aspergillus species.
Q: What is the mechanism of action of Micafungin?
A: Micafungin works by inhibiting the enzyme β-1,3-D-glucan synthase, which is essential for the synthesis of β-1,3-glucan, a crucial component of fungal cell walls. This inhibition leads to cell wall instability and ultimately fungal cell death.
Q: What are the main clinical uses of Micafungin?
A: Micafungin is primarily used for: - Treatment of candidemia and certain invasive forms of candidiasis - Treatment of esophageal candidiasis - Prophylaxis of Candida infections in hematopoietic stem cell transplant (HSCT) recipients
Q: What are the common side effects of Micafungin?
A: Common side effects of Micafungin include: - Histamine-mediated infusion-related reactions - Injection site reactions - Transient abnormalities of liver enzymes In rare cases, significant hepatic or renal dysfunction, hepatitis, or liver/renal failure have been reported.
Q: How is Micafungin administered?
A: Micafungin is formulated as the monosodium salt for intravenous infusion. Unlike some other echinocandins, a loading dose is not required for Micafungin.
Q: Are there any significant drug interactions with Micafungin?
A: Yes, potentially hazardous interactions have been reported with: - Ciclosporin: Micafungin may increase ciclosporin concentration - Sirolimus: Micafungin increases sirolimus concentration It's important to consult with a healthcare professional for a complete list of potential drug interactions.
Company Name | Contact | Product Details |
---|---|---|
AFINE CHEMICALS LIMITED | Tel: 86 0571 85134551 | Purity: 98%, Package: Standard or custom |
Shaanxi Haibo Biotechnology Co., Ltd. | Tel: 18602966907 | Purity: 99%, Package: 25kg, White Powder |
Henan Tianfu Chemical Co., Ltd. | Tel: 86 0371 55170693, 86 19937530512 | Purity: 99%, Package: 25KG, 5KG, 1KG |
Shanghai Yingrui Biopharma Co., Ltd. | Tel: 86 21 33585366-03 | Purity: 99%, Package: 100g, 500g, 1kg, 25kg |
ATK CHEMICAL COMPANY LIMITED | Tel: 21 51877795 | Purity: 98%, Package: 500MG, 1G, 5G, 10G, 50G, 100G |
This article was written by bob and published on 2024-07-14 02:30:04. Original article, reproduction is prohibited. The content is for entertainment purposes only and should not be taken as fact.
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