Floxuridine (CAS 50-91-9) Suppliers and Product Information

Floxuridine is a nucleoside ***og that inhibits the enzyme ribonucleotide reductase, which is involved in DNA synthesis. It is used in the palliative treatment of gastrointestinal adenocarcinoma with liver metastases and has antiviral and antineoplastic properties.

Frequently Asked Questions about Floxuridine

Q: What is the main use of Floxuridine?

A: Floxuridine is primarily used in the palliative treatment of gastrointestinal adenocarcinoma with liver metastases. It also has applications in treating malignant neoplasms of the liver and gastrointestinal tract.

Q: How does Floxuridine work?

A: Floxuridine works by inhibiting the enzyme ribonucleotide reductase, which is involved in DNA synthesis. It is metabolically converted to 5-fluorouracil (5-FU) metabolites, resulting in the inhibition of thymidylate synthase, thus disrupting DNA synthesis, function, and repair.

Q: What are the potential side effects of Floxuridine?

A: Common side effects may include gastrointestinal effects such as nausea, vomiting, and diarrhea. It can also cause bone marrow changes and allergic dermatitis. As with other chemotherapy drugs, it may have more severe side effects and should be administered under medical supervision.

Q: How is Floxuridine administered?

A: Floxuridine is typically administered intravenously or intra-arterially. It is poorly absorbed from the gastrointestinal tract when taken orally.