Econazole Nitrate (CAS 68797-31-9) Suppliers and Product Information

Econazole nitrate is a broad-spectrum antifungal medication used topically for treating various fungal infections such as athlete's foot, jock itch, ringworm, and pityriasis. It is also used vaginally to treat vaginal candidiasis.

**Physical Properties:** - Appearance: White crystalline powder - Solubility: Slightly soluble in water and most organic solvents - Density: 1.6311 g/cm³ (estimated) - Refractive Index: 1.6200 (estimated) - Water Solubility: 711.5 mg/L at 25°C

**Pharmacological Action:** Econazole nitrate works by disrupting the fungal cell membrane's ergosterol biosynthesis, leading to increased permeability and cell death. It also inhibits various enzymatic activities in fungal cells, causing accumulation of hydrogen peroxide and cellular degeneration.

**Usage:** Primarily used for treating tinea infections (corporis, manuum, pedis, cruris), tinea versicolor, and cutaneous candidiasis.

Frequently Asked Questions

**Q: What is the recommended duration of treatment with econazole nitrate?**

A: To avoid relapses, patients with cutaneous candidiasis and various tinea diseases typically require at least a 2-week course of therapy. For tinea pedis, a minimum 4-week course is recommended.

**Q: Are there any precautions when using econazole nitrate?**

A: Yes, econazole nitrate is intended for external use only. Avoid contact with eyes and do not use it on large areas or for prolonged periods. It should not be used with tight dressings in the treatment of candidiasis.

**Q: What are the possible adverse reactions to econazole nitrate?**

A: Local irritation symptoms such as pruritus and burning sensation may occur. Occasionally, patients may experience erythema and blisters, but these are usually short-lived and mild.