Ranitidine (CAS 66357-35-5) Suppliers and Product Information

Ranitidine is a histamine H2-receptor antagonist used to treat peptic ulcer disease and gastroesophageal reflux disease. It reduces gastric acid secretion and pepsin activity. The drug is available in various dosage forms, including as a hydrochloride salt and a bismuth citrate salt.

Frequently Asked Questions about Ranitidine

What is Ranitidine used for?

Ranitidine is primarily used to treat conditions associated with hyperacidity, including peptic ulcer disease, gastroesophageal reflux disease, and other conditions accompanied by elevated acidity of the gastrointestinal tract.

How does Ranitidine work?

Ranitidine works as a potent, selective, and competitive histamine H2 receptor antagonist. It inhibits gastric acid secretion induced by various stimuli, including histamine, pentagastrin, bethanecol, and food.

Are there any drug interactions with Ranitidine?

Yes, Ranitidine may interact with several drugs. Notable interactions include reduced absorption of certain antifungals and antivirals, potential effects on ciclosporin levels, and interactions with some cytotoxic drugs. It's important to consult with a healthcare professional about potential drug interactions.

How is Ranitidine metabolized?

Ranitidine is not extensively metabolized. A small proportion is metabolized in the liver to the N-oxide, S-oxide, and desmethylranitidine. The N-oxide is the major metabolite but accounts for only about 4-6% of a dose. The drug and its metabolites are primarily excreted in urine, with some excretion in feces.