Yohimbine Hydrochloride (CAS 65-19-0) Suppliers and Product Information

Yohimbine hydrochloride is an α2-adrenergic receptor antagonist used in the treatment of erectile dysfunction and neurological disorders. It is derived from the bark of the Coryanthe yohimbe tree and acts by blocking central α2-adrenergic receptors in the brain. The compound increases sympathetic outflow, heart rate, and blood pressure, and has antidiuretic effects.

Frequently Asked Questions about Yohimbine Hydrochloride

What are the main uses of Yohimbine hydrochloride?

Yohimbine hydrochloride is primarily used for treating erectile dysfunction. It is also used in veterinary medicine to reverse the effects of xylazine in dogs and other animals. Additionally, it has applications in treating certain neurological disorders and as a research chemical.

What are the side effects of Yohimbine hydrochloride?

Common side effects include high blood pressure, increased heart rate, headache, anxiety, dizziness, nausea, vomiting, tremors, and sleeplessness. It can be dangerous if taken in large doses or for extended periods.

How does Yohimbine hydrochloride work?

Yohimbine hydrochloride works as a pre-synaptic alpha-2 adrenergic blocking agent. It increases sympathetic drive by blocking central alpha-2 adrenergic receptors, leading to increased norepinephrine release and firing rate of noradrenergic nuclei in the brain.

Are there any contraindications for Yohimbine hydrochloride use?

Yohimbine should not be taken with MAO inhibitors. It should be used with caution in combination with blood pressure medications, tricyclic antidepressants, or phenothiazines. People with kidney problems or psychiatric conditions should avoid its use. It is not recommended for pregnant or breastfeeding women.