Cemandil sodium salt (CAS 42540-40-9) Suppliers and Product Information

Cemandil sodium salt, also known as Cefamandole Nafate, is a second-generation cephalosporin antibiotic. It is a prodrug with R-O-formylmandelamido and N-methylthiotetrazole side groups. The compound is used for treating various bacterial infections, including lower respiratory tract, skin and skin structures, bone and joint infections, septicemia, and urinary tract infections when the organisms are sensitive.

Frequently Asked Questions about Cemandil sodium salt

Q: What is the mechanism of action of Cemandil sodium salt?

A: Cemandil sodium salt (Cefamandole nafate) has a formylated D-mandelic amide moiety at C-7. The formate ester is rapidly cleaved in the host to release the more active cefamandole. It has increased activity against Haemophilus influenzae and some Gram-negative bacilli compared to first-generation cephalosporins. The 5-thio-1-methyl-1H-tetrazole moiety at C-3 enhances potency and prevents metabolism by deacetylation.

Q: What are the main clinical uses of Cemandil sodium salt?

A: Cemandil sodium salt is primarily used for treating lower respiratory tract infections, skin and skin structure infections, bone and joint infections, septicemia, and urinary tract infections caused by sensitive organisms. It is particularly effective against some beta-lactamase-producing Gram-negative bacteria that show resistance to first-generation cephalosporins.

Q: Are there any specific precautions or side effects associated with Cemandil sodium salt?

A: Yes, there are some precautions to consider. The 5-thio-1-methyl-1H-tetrazole moiety can be associated with prothrombin deficiency and bleeding problems. It may also cause an Antabuse-like acute alcohol intolerance. As with other antibiotics, it should be used cautiously and only when necessary to prevent the development of antibiotic-resistant bacteria.