Valinomycin (CAS 2001-95-8) Suppliers and Product Information

Valinomycin is a cyclic depsipeptide antibiotic and a potassium-selective ionophore. It is capable of transporting potassium ions through lipid membranes and can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential. It has applications in research as an insecticide, nematocide, and as a biosensor for detecting potassium efflux.

Frequently Asked Questions about Valinomycin

Q: What is the primary use of Valinomycin?

A: Valinomycin is primarily used as a selective potassium ionophore in research. It has applications in studying ion transport across membranes, inducing apoptosis in cells, and as an insecticide and nematocide.

Q: How does Valinomycin work?

A: Valinomycin works by selectively binding to potassium ions and facilitating their transport across lipid membranes. This action can lead to a loss of mitochondrial membrane potential and induce various cellular effects, including apoptosis.

Q: What are the safety precautions for handling Valinomycin?

A: Valinomycin is highly toxic and should be handled with care. It can be irritant to eyes and skin, and inhalation can cause breathing difficulties. Always use appropriate personal protective equipment and work in a well-ventilated area. In case of exposure, seek immediate medical attention.

Q: How should Valinomycin be stored?

A: Valinomycin should be stored at -20°C. Solutions in DMSO can be stored at -20°C for up to 3 months.