Bafetinib (CAS 887650-05-7) Suppliers and Product Information

Bafetinib is a potent and selective dual inhibitor of Bcr-Abl/Lyn tyrosine kinase with IC50 values of 5.8nM and 19nM, respectively. It is used as an investigational drug for the treatment of chronic myeloid leukemia (CML). Bafetinib can block the autophosphorylation of Bcr-Abl and suppress the growth of Bcr-Abl–positive leukemic cell lines.

Frequently Asked Questions

Q: What is the mechanism of action of Bafetinib?

A: Bafetinib is a specific dual Abl-Lyn inhibitor. It blocks the autophosphorylation of Bcr-Abl and inhibits the growth of Bcr-Abl–positive leukemic cell lines.

Q: How should Bafetinib be stored?

A: Bafetinib should be stored under inert gas (nitrogen or argon) at 2-8°C.

Q: What is the solubility of Bafetinib?

A: Bafetinib has a solubility of ≥57.7 mg/mL in DMSO. It is insoluble in ethanol and water.