Rufloxacin (CAS: 101363-10-4) Suppliers and Product Information

Rufloxacin is a tricyclic fluoroquinolone antibiotic. It is primarily used for urinary tract infections and chronic prostatitis, although clinical experience is limited. The compound shows weak activity against Enterobacteriaceae and poor activity against Pseudomonas aeruginosa. It is inactive against Gram-positive cocci.

Frequently Asked Questions about Rufloxacin

Q: What is the primary use of Rufloxacin?

A: Rufloxacin is primarily used for treating urinary tract infections and chronic prostatitis. However, its clinical use is limited compared to other fluoroquinolone antibiotics.

Q: What is the typical dosage and administration of Rufloxacin?

A: Based on limited clinical experience, Rufloxacin has been administered with loading doses of 400 and 600 mg, followed by 9 days of either 200 or 300 mg daily. The mean peak plasma levels were around 4.5-7 mg/L respectively.

Q: What are the pharmacokinetic properties of Rufloxacin?

A: Rufloxacin has a mean apparent elimination half-life of approximately 44 hours. About 50% of the drug is eliminated in the urine.

Q: Is Rufloxacin effective against all types of bacteria?

A: No, Rufloxacin has varying effectiveness against different bacteria. It is inactive against Gram-positive cocci, shows weak activity against Enterobacteriaceae, and has poor activity against Pseudomonas aeruginosa.