Felodipine (CAS 86189-69-7) Suppliers and Product Information

Felodipine is a calcium channel blocker used as a vasodilator for treating hypertension and angina. It is marketed under the brand name Plendil by AstraZeneca. The drug is metabolized in the liver, with approximately 70% of a given dose excreted as metabolites in urine and about 10% in feces. Less than 0.5% of the dose is excreted unchanged in urine.

**Drug Interactions:** Felodipine may interact with aminophylline, theophylline, anesthetics, certain antibacterials, antidepressants, antiepileptics, antifungals, antihypertensives, antivirals, grapefruit juice, and tacrolimus. Caution is advised when using these medications concurrently.

Frequently Asked Questions about Felodipine

Q: What is the main use of Felodipine?

A: Felodipine is primarily used as a calcium channel blocker for treating hypertension (high blood pressure) and angina (chest pain).

Q: How is Felodipine metabolized in the body?

A: Felodipine is metabolized in the liver. About 70% of a given dose is excreted as metabolites in urine, 10% in feces, and less than 0.5% is excreted unchanged in urine.

Q: Are there any significant drug interactions with Felodipine?

A: Yes, Felodipine may interact with several medications, including aminophylline, theophylline, anesthetics, certain antibacterials, antidepressants, antiepileptics, antifungals, antihypertensives, and antivirals. It's also important to avoid grapefruit juice while taking Felodipine.

Q: What is the BCS class of Felodipine?

A: Felodipine belongs to BCS Class 2, which typically indicates low solubility and high permeability.