Silver Sulfadiazine (CAS 22199-08-2) Suppliers and Product Information

Silver sulfadiazine is a synthetic antimicrobial agent that combines the beneficial properties of silver nitrate and sulfonamides. It is primarily used as an adjunct in the prevention and treatment of wound sepsis in patients with second and third-degree burns. It is also effective against many Gram-positive and Gram-negative bacteria, as well as C. albicans, and shows good efficacy against P. aeruginosa and S. aureus.

The compound acts upon the cell membrane and cell wall of microorganisms. It is highly insoluble in water, which prevents hypochloraemia in burns patients, unlike silver nitrate. Silver sulfadiazine is typically applied as a cream and kept on the burned skin throughout the healing period or until a graft is applied.

Frequently Asked Questions about Silver Sulfadiazine

Q: What is the main use of Silver sulfadiazine?

A: Silver sulfadiazine is primarily used for the prevention and treatment of wound sepsis in patients with second and third-degree burns. It is also used for wound care of chronic ulcers.

Q: How does Silver sulfadiazine work?

A: Silver sulfadiazine acts upon the cell membrane and cell wall of microorganisms. It is bactericidal against many Gram-positive and Gram-negative bacteria, as well as effective against C. albicans, P. aeruginosa, and S. aureus.

Q: Are there any side effects of using Silver sulfadiazine?

A: Some patients may experience a stinging sensation upon application. As the compound can be absorbed, systemic sulfonamide reactions similar to those caused by sulfonamides may occur. Caution should be exercised when applying to large areas, as sulfadiazine levels in the plasma may reach therapeutic levels that can cause side effects.

Q: Is Silver sulfadiazine used in veterinary medicine?

A: Yes, Silver sulfadiazine cream has been used in veterinary medicine, particularly for treating fungal keratitis in horses. It has shown promising results, especially when used early in the course of the disease.