Cisplatin (CAS 15663-27-1) Suppliers and Product Information

Cisplatin is a potent anticancer agent that blocks DNA synthesis and induces apoptosis via p53-dependent and -independent mechanisms. It is used in the treatment of various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and brain cancers. Cisplatin works by forming DNA adducts, primarily intrastrand crosslink adducts, which activate several signal transduction pathways and culminate in the activation of apoptosis.

Frequently Asked Questions

Q: What is the mechanism of action of cisplatin?

A: Cisplatin acts as a DNA-damaging agent by forming covalent bonds with purine bases in DNA, creating DNA adducts. This leads to DNA damage responses, cell cycle arrest, and ultimately apoptosis in cancer cells.

Q: How should cisplatin be stored?

A: Cisplatin should be stored at 2-8°C in dark and dry conditions, preferably in a desiccator.

Q: What are the common side effects of cisplatin?

A: Common side effects of cisplatin include nephrotoxicity, ototoxicity, neurotoxicity, and myelosuppression. It can also cause nausea, vomiting, and electrolyte imbalances.