Galanthamine Hydrobromide (CAS 69353-21-5): Supplier Information and Product Details

Galanthamine Hydrobromide is a competitive and reversible inhibitor of acetylcholinesterase. It acts as an antimyasthenic agent and can partially reverse the effects of scopolamine-induced amnesia in rats. This compound is known to improve learning and short-term memory in animal models.

Chemical Properties: - Form: White solid - Storage: Sealed in dry conditions at room temperature - Purity: ≥99% (as offered by most suppliers) Safety Information: Hazard Class: 6.1(b) Risk Statements: 25 Safety Statements: 45 WGK Germany: 3 RTECS: DF8075000

Clinical Use: Galantamine, introduced in 2001, is an alkaloid found in plants of the Amaryllidaceae family. It is indicated for the treatment of mild to moderate Alzheimer's Disease and dementia. It has also been used as an anticurare agent in anesthesia outside the U.S. for over 30 years.

Metabolism: Galantamine is metabolized (75%) by CYP2D6 and CYP3A4 enzymes. Its elimination half-life is 5-7 hours. Unlike some other cholinesterase inhibitors, galantamine is not associated with hepatotoxicity.

Frequently Asked Questions about Galanthamine Hydrobromide

Q: What is the primary mechanism of action of Galanthamine Hydrobromide? A: Galanthamine Hydrobromide is a competitive and reversible inhibitor of acetylcholinesterase. It also has a unique dual cholinergic action as it allosterically binds to nicotinic receptors.

Q: What are the main clinical applications of Galanthamine Hydrobromide? A: Galanthamine Hydrobromide is primarily used for the treatment of mild to moderate Alzheimer's Disease and dementia. It has also been used as an anticurare agent in anesthesia.

Q: How does Galanthamine Hydrobromide differ from other cholinesterase inhibitors? A: Galanthamine Hydrobromide is unique because it has a dual cholinergic action. It not only inhibits acetylcholinesterase but also allosterically binds to nicotinic receptors. Additionally, unlike some other cholinesterase inhibitors like tacrine, galantamine is not associated with hepatotoxicity.

Q: What is the typical purity of commercially available Galanthamine Hydrobromide? A: Based on the supplier information provided, most manufacturers offer Galanthamine Hydrobromide with a purity of ≥99%.