Property | Information |
---|---|
Product Name | Cefoperazone sodium |
CAS Number | 62893-20-3 |
Molecular Formula | C25H28N9NaO8S2 |
Molecular Weight | 669.66 |
Melting Point | 200-202°C |
Storage Temperature | 2-8°C (Inert atmosphere) |
Solubility | Soluble in water (50-160 mg/mL), slightly soluble in alcohol |
Form | Powder |
Color | White to Off-White |
Stability | Hygroscopic |
Cefoperazone sodium is a third-generation cephalosporin antibiotic with broad-spectrum activity against gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. It was synthesized by Toyama Chemicals Co. in 1978 and is primarily excreted in bile. The drug shows excellent activity against various bacterial strains and has unique pharmacological characteristics, including high bile concentrations and moderate transfer into cerebrospinal fluid.
Q: What is the mechanism of action of Cefoperazone sodium?
A: Cefoperazone sodium interferes with bacterial cell wall synthesis, which is its primary mechanism of action as an antibiotic.
Q: What are the main clinical uses of Cefoperazone sodium?
A: Cefoperazone sodium is used to treat serious infections, particularly those caused by susceptible Enterobacteriaceae that are not responsive to other less expensive agents. It is also used when aminoglycosides are contraindicated due to their potential toxicity.
Q: How is Cefoperazone sodium administered?
A: Cefoperazone sodium is typically administered intravenously. In clinical studies, it has been shown to achieve high concentrations in bile and gallbladder tissue after intravenous administration.
Q: What is the stability of Cefoperazone sodium to β-lactamases?
A: Cefoperazone is relatively stable to hydrolysis by β-lactamases produced by gram-negative bacteria. However, it can be hydrolyzed by some β-lactamases that typically hydrolyze penicillins and certain cephalosporins.
Company Name | Contact | Product Details |
---|---|---|
Shenzhen Excellent Biomedical Technology Co., Ltd. | Tel: 86-0755-26050679, 86-15915472436 | Purity: ≥95%, Package: 10mg, 25mg, 50mg, 100mg |
Hebei Mojin Biotechnology Co., Ltd. | Tel: 86-13288715578 | Purity: 99%, Package: 25KG |
Shaanxi TNJONE Pharmaceutical Co., Ltd. | Tel: 8618740459177 | Purity: 99%, Package: 1kg |
Ouhuang Engineering Materials Hubei Co., Ltd. | Tel: 86-86177 | Purity: 99.912%, Package: 1kg, Price: 15USD |
Henan Tianfu Chemical Co., Ltd. | Tel: 86-0371-55170693, 86-19937530512 | Purity: 99%, Package: 25KG, 5KG, 1KG |
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