Prochlorperazine Maleate (CAS 84-02-6) Suppliers and Product Information

Prochlorperazine maleate is a phenothiazine antipsychotic and D2 dopamine receptor antagonist. It has antiemetic, antispasmodic, and antinociceptive properties. The compound inhibits dynamin and clathrin-mediated endocytosis with an IC50 of 5-8 μM for CME. It is used clinically as an antiemetic and for its antimigraine effects.

Frequently Asked Questions about Prochlorperazine Maleate

Q: What are the main uses of Prochlorperazine Maleate?

A: Prochlorperazine Maleate is primarily used as an antiemetic to prevent nausea and vomiting. It also has applications in treating migraines and as an antipsychotic, though its use for the latter is less common due to the high prevalence of extrapyramidal side effects.

Q: How does Prochlorperazine Maleate work?

A: Prochlorperazine Maleate acts as a D2 dopamine receptor antagonist. It also interacts with 5-HT3 and nAChR receptors. Its antiemetic effects are believed to be due to its action on the chemoreceptor trigger zone in the central nervous system.

Q: What are some common brand names for Prochlorperazine Maleate?

A: Common brand names for Prochlorperazine Maleate include Compazine, Stemetil, and Buccastem.

Q: What is the typical purity of commercially available Prochlorperazine Maleate?

A: Based on the supplier information provided, commercially available Prochlorperazine Maleate typically has a purity ranging from 98% to 99.99%.