Lorazepam (CAS 846-49-1): Properties, Uses, and Supplier Information

Lorazepam is a white crystalline solid that is practically insoluble in water, sparingly soluble in ethanol (96%), and sparingly or slightly soluble in methylene chloride. It has pKa values of 1.3 (pK1) and 11.5 (pK2) at 25°C.

Lorazepam is a benzodiazepine that acts as a ligand at the GABAA receptor benzodiazepine modulatory site. It has anxiolytic, anticonvulsant, and sedative/hypnotic properties.

The compound was first developed by Wyeth in Italy in 1972 under the brand name Tavor. It is also known by other brand names such as Ativan (Baxter Healthcare, Biovail) and Loraz (Quantum Pharmics).

Frequently Asked Questions about Lorazepam

Q: What is the main use of Lorazepam?

A: Lorazepam is primarily used as an anxiolytic (anti-anxiety) medication. It also has anticonvulsant and sedative/hypnotic properties, making it useful for treating various conditions such as anxiety disorders, insomnia, and seizures.

Q: How does Lorazepam work in the body?

A: Lorazepam acts as a ligand at the benzodiazepine modulatory site of GABAA receptors in the brain. By enhancing the effects of GABA (gamma-aminobutyric acid), the primary inhibitory neurotransmitter in the central nervous system, it produces calming and sedative effects.

Q: Is Lorazepam a controlled substance?

A: Yes, Lorazepam is classified as a controlled substance in many countries due to its potential for abuse and dependence. It is typically scheduled as a prescription medication and its use is regulated.

Q: What are the potential side effects of Lorazepam?

A: Common side effects of Lorazepam may include drowsiness, dizziness, weakness, and unsteadiness. More serious side effects can include respiratory depression, especially when combined with other central nervous system depressants. As with all ***, there is a risk of physical dependence with prolonged use.