Cilazapril (CAS 88768-40-5) Suppliers and Product Information

Cilazapril is a potent ACE inhibitor used for treating hypertension. It is a prodrug that is hydrolyzed after absorption to its active form, cilazaprilat. Cilazapril functions as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is an ethyl ester, a pyridazinodiazepine, and a dicarboxylic acid monoester.

Cilazapril has been shown to inhibit plasma ACE activity and the angiotensin I-induced pressor response in anesthetized rats and cats at doses as low as 0.1 mg/kg. It can decrease systolic blood pressure in spontaneously hypertensive rats at a dose of 30 mg/kg and reduce blood pressure in volume-depleted renal hypertensive dogs at 10 mg/kg p.o.

Frequently Asked Questions about Cilazapril

Q: What is the primary use of Cilazapril?

A: Cilazapril is primarily used in the treatment of hypertension (high blood pressure) and heart failure.

Q: How does Cilazapril work?

A: Cilazapril is a prodrug that is hydrolyzed after absorption to its active form, cilazaprilat. It works by inhibiting the angiotensin-converting enzyme (ACE), which helps to relax blood vessels and lower blood pressure.

Q: What is the purity of commercially available Cilazapril?

A: The purity of commercially available Cilazapril typically ranges from 98% to 99.9%, depending on the supplier and intended use.

Q: How should Cilazapril be stored?

A: Cilazapril should be stored at a temperature between 2-8°C (35.6-46.4°F) to maintain its stability.