Sucralfate (CAS 54182-58-0) Suppliers and Product Information

Sucralfate is a complex of the sulfuric acid ester of sucrose and aluminum hydroxide. It is used as an antacid and antiulcer medication. The compound forms a viscous adherent complex in the stomach, which is believed to inhibit back diffusion of H ions and reduce pepsin activity. It also stimulates the synthesis and release of prostaglandins, bicarbonate, and growth factors, aiding in ulcer healing.

Frequently Asked Questions about Sucralfate

Q: What is the main use of Sucralfate?

A: Sucralfate is primarily used as an antacid and antiulcer medication. It forms a protective barrier over ulcer sites in the stomach and duodenum, preventing further damage from stomach acid and pepsin.

Q: How does Sucralfate work?

A: Sucralfate works by forming a viscous, adherent complex when exposed to gastric acid. This complex binds to the ulcer site, creating a protective barrier. It also inhibits pepsin activity, stimulates prostaglandin production, and may promote tissue healing.

Q: Are there any drug interactions with Sucralfate?

A: Yes, Sucralfate can interact with several medications. It may reduce the absorption of drugs like tetracyclines, quinolones, phenytoin, digoxin, and cimetidine. It's recommended to separate the administration of these drugs from Sucralfate by at least 2 hours.

Q: What are the common side effects of Sucralfate?

A: The most frequently reported adverse reaction to Sucralfate is constipation. Other potential side effects are generally mild and may include nausea, dry mouth, and stomach discomfort.

Q: Is Sucralfate absorbed into the bloodstream?

A: Sucralfate is minimally absorbed from the gastrointestinal tract. Only small amounts enter the bloodstream, which is why it primarily exerts its effects locally in the stomach and intestines.