Resibufogenin (CAS 465-39-4) Suppliers and Product Information

Resibufogenin is a specific inhibitor of Na /K -ATPase and a component of huachansu. It has shown anti-proliferative effects against cancer cells. Resibufogenin is used for content determination, identification, and pharmacological experiments. It acts as a cardiotonic, central nervous system (CNS) respiratory agent, ***gesic, anesthetic, and as a remedy for ulcers.

Resibufogenin exhibits its anticancer properties by triggering necrosis through up-regulation of receptor-interacting protein kinase 3 (RIP3) and phosphorylation of mixed lineage kinase domain-like protein. It induces apoptosis, increases caspase-3 and caspase-8 activity, and affects the expression of various proteins involved in cell cycle regulation and signaling pathways.

Frequently Asked Questions about Resibufogenin

Q: What is the main use of Resibufogenin?

A: Resibufogenin is primarily used in research as a specific inhibitor of Na /K -ATPase. It has shown potential anticancer properties and is used in pharmacological experiments, content determination, and identification studies.

Q: How should Resibufogenin be stored?

A: Resibufogenin should be stored under inert gas (nitrogen or Argon) at 2-8°C to maintain its stability.

Q: What is the typical purity of commercially available Resibufogenin?

A: The purity of commercially available Resibufogenin is typically ≥98%.

Q: Is Resibufogenin able to cross the blood-brain barrier?

A: Yes, Resibufogenin is reported to be BBB (blood-brain barrier) permeant.