Property | Value |
---|---|
Product Name | Trimetazidine |
CAS Number | 5011-34-7 |
Molecular Formula | C14H22N2O3 |
Molecular Weight | 266.34 |
EINECS | 225-690-2 |
Boiling Point | 200-205°C |
Density | 1.092 ± 0.06 g/cm3 |
Predicted Vapor Pressure | 0.003Pa at 25°C |
Storage | Hygroscopic, Refrigerator, Under inert atmosphere |
Solubility | Slightly soluble in Chloroform and Methanol |
Form | Solid |
pKa | 9.07 ± 0.10 |
Color | Colorless to Pale Yellow Gel |
LogP | 1.143 at 25°C and pH 6 |
Trimetazidine is a piperazine derivative used for the symptomatic treatment of stable angina pectoris. It acts as an anti-angina drug by antagonizing ***, norepinephrine, and vasopressin. The drug relaxes vascular smooth muscle, reduces vascular resistance, increases coronary and peripheral blood flow, promotes myocardial metabolism, and reduces myocardial oxygen consumption.
A: Trimetazidine is primarily used for the treatment of coronary insufficiency, angina pectoris, and old myocardial infarction. It can also be used in combination with digitalis in patients with severe heart failure.
A: Trimetazidine works by providing direct cell protection to the heart. It conserves energy metabolism in ischemic oxygen cells, maintains intracellular environment stability, ensures proper ion pump function, reduces intracellular acidosis, and protects against cell damage caused by oxygen free radicals.
A: A few patients may experience gastrointestinal discomfort, nausea, and vomiting when taking Trimetazidine.
A: Trimetazidine is contraindicated in patients with allergies and new myocardial infarction. Pregnant women and lactating mothers should use this drug with caution. For safety reasons, it's advisable to consult a healthcare professional before use.
Company Name | Contact Information | Product Details |
---|---|---|
Henan Tianfu Chemical Co., Ltd. | Tel: 86 0371 55170693, 86 19937530512 | Purity: 99%, Package: 25KG/5KG/1KG |
CONIER CHEM AND PHARMA LIMITED | Tel: 8618523575427 | Purity: ≥99%, Package: 1kg |
Career Henan Chemical Co. | Tel: 86 0371 86658258, 8613203830695 | Purity: 98%, Package: 1g (1USD) |
Hefei TNJ Chemical Industry Co., Ltd. | Tel: 0551-65418671 | Not specified |
Xi'an MC Biotech Co., Ltd. | Tel: 029-89275612, 8618991951683 | Purity: 98%, Package: 1G/10G/1KG/5KG/10KG |
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