Doripenem (CAS 148016-81-3) Suppliers and Product Information

Doripenem is an ultra-broad spectrum injectable β-lactam antibiotic belonging to the carbapenem subgroup. It is used to treat complicated urinary tract infections, intra-abdominal infections, and nosocomial pneumonia. Doripenem acts by inhibiting bacterial cell wall synthesis, leading to cell death.

Frequently Asked Questions about Doripenem

What is the mechanism of action of Doripenem?

Doripenem's bactericidal function is due to its inhibition of the third stage of bacterial cell wall synthesis. It binds to penicillin-binding proteins, weakening the cell wall and leading to cell death due to lysis.

What is the spectrum of activity for Doripenem?

Doripenem has a broad spectrum of activity against both gram-positive and gram-negative aerobic bacteria. It is particularly effective against Pseudomonas aeruginosa, potentially more potent than meropenem in vitro.

What are the common side effects of Doripenem?

The most commonly reported adverse effects include pain or swelling at the injection site, nausea, headache, and diarrhea. Seizures and central nervous system side effects are observed rarely (<1%).

How is Doripenem administered?

Doripenem is administered intravenously. The usual dose is 250 mg infused over 30 to 60 minutes, 2 or 3 times a day. The maximum dose is 500 mg per administration, up to a total dose of 1500 mg/day.