Duloxetine (CAS 116539-59-4) Suppliers and Product Information

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used primarily as an antidepressant. It is also approved for the treatment of diabetic peripheral neuropathic pain. The drug works by inhibiting the reuptake of serotonin and norepinephrine in the central nervous system, leading to increased neurotransmitter levels.

Frequently Asked Questions about Duloxetine

Q: What are the main uses of Duloxetine?

A: Duloxetine is primarily used as an antidepressant and for the treatment of diabetic peripheral neuropathic pain. It is also prescribed for generalized anxiety disorder and fibromyalgia.

Q: How does Duloxetine work?

A: Duloxetine works by inhibiting the reuptake of serotonin and norepinephrine in the central nervous system. This action increases the levels of these neurotransmitters, which is believed to improve mood and reduce pain perception.

Q: What are the potential side effects of Duloxetine?

A: Common side effects may include nausea, dry mouth, constipation, decreased appetite, fatigue, drowsiness, and increased sweating. It's important to consult a healthcare professional for a complete list of potential side effects and drug interactions.

Q: How is Duloxetine metabolized in the body?

A: Duloxetine is extensively metabolized in the liver, primarily by CYP2D6 and CYP1A2 enzymes. The major metabolites are excreted in urine as glucuronide and sulfate conjugates.