Property | Information |
---|---|
Product Name | Geldanamycin |
CAS Number | 30562-34-6 |
Molecular Formula | C29H40N2O9 |
Molecular Weight | 560.64 |
Appearance | Yellow to orange powder |
Purity | ≥99% (typically) |
Melting Point | 255-176°C |
Solubility | DMSO soluble |
Storage | -20°C |
Stability | Stable for 2 years from date of purchase as supplied |
Geldanamycin is a benzoquinone ansamycin antibiotic with potent antitumor properties. It specifically binds to and inhibits the heat shock protein 90 (Hsp90) chaperone, interfering with cellular stress responses and the conformational maturation of various proteins. This compound has shown activity against multiple cell lines and in mouse tumor models, making it a promising candidate for cancer research and potential therapeutic development.
Q: What is the primary mechanism of action for Geldanamycin?
A: Geldanamycin primarily acts by binding to and inhibiting the chaperone functions of heat shock protein 90 (Hsp90). This interaction disrupts the stability and function of various oncogenic signaling proteins, interfering with cellular stress responses and protein maturation.
Q: What are the potential applications of Geldanamycin?
A: Geldanamycin shows promise in cancer research and therapy due to its ability to inhibit multiple oncogenic proteins. It has demonstrated antiproliferative and antitumor effects in various cell lines and mouse tumor models.
Q: How should Geldanamycin be stored?
A: Geldanamycin should be stored at -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Q: What is the recommended solvent for Geldanamycin?
A: Geldanamycin is soluble in DMSO (dimethyl sulfoxide).
Company Name | Contact Information | Product Details |
---|---|---|
Hebei Mojin Biotechnology Co., Ltd. | Tel: 86 13288715578 | Purity: 99%, Package: 25KG |
Hebei Yanxi Chemical Co., Ltd. | Tel: 86 17531190177 | Purity: ≥99%, Package: 1kg-1000kg, Factory direct sales |
Henan Tianfu Chemical Co., Ltd. | Tel: 86 0371 55170693, 86 19937530512 | Purity: 99%, Package: 25KG, 5KG, 1KG |
Hubei XinRunde Chemical Co., Ltd. | Tel: 8615102730682 | Purity: 99%, Package: 100g bag, 2kg bag, 25kg carton or as required |
Career Henan Chemical Co. | Tel: 86 0371 86658258, 8613203830695 | Purity: 99%, Package: 1KG |
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