Losartan Carboxylic Acid (CAS 124750-92-1) Suppliers and Product Information

Losartan Carboxylic Acid is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. It is a potent angiotensin II receptor type 1 (AT1) antagonist with Ki values of 0.57 nM and 0.67 nM for rat and human forms, respectively. This compound produces depressor responses and vasodilation, and when administered intravenously, it is more potent and has a longer duration of action than losartan.

Frequently Asked Questions

Q: What is the main use of Losartan Carboxylic Acid?

A: Losartan Carboxylic Acid is primarily used as a metabolite of Losartan in research settings. It is a potent AT1 antagonist, producing depressor responses and vasodilation, making it valuable for studying cardiovascular effects and angiotensin II receptor interactions.

Q: How should Losartan Carboxylic Acid be stored?

A: Losartan Carboxylic Acid should be stored at -20°C under inert atmosphere conditions to maintain its stability.

Q: Is Losartan Carboxylic Acid more potent than Losartan?

A: Yes, when administered intravenously, Losartan Carboxylic Acid is more potent and has a longer duration of action than Losartan. However, it has very low oral bioavailability.