Pentagastrin (CAS 5534-95-2) Suppliers and Product Information

Pentagastrin is a synthetic polypeptide and cholecystokinin 2 (CCK2) receptor agonist. It stimulates gastric acid secretion, pepsin secretion, and intrinsic factor production. Pentagastrin is used as a diagnostic aid to evaluate gastric acid secretory function.

Frequently Asked Questions about Pentagastrin

Q: What is the primary use of Pentagastrin?

A: Pentagastrin is primarily used as a diagnostic agent to evaluate gastric acid secretory function. It is useful in testing for anacidity in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma, as well as hypersecretion in suspected duodenal ulcer, postoperative stomal ulcers, and Zollinger-Ellison tumor.

Q: How does Pentagastrin work?

A: Pentagastrin is a CCK2 receptor agonist that binds selectively to CCK2 receptors. It increases calcium influx and polyphosphoinositide turnover in cells, stimulates gastric acid and pepsin secretion, and induces contraction of smooth muscle cells.

Q: What are the pharmacological properties of Pentagastrin?

A: Pentagastrin has properties similar to natural gastrins. It stimulates gastric secretion, pepsin secretion, gastric motility, pancreatic secretion of water and bicarbonate, pancreatic enzyme secretion, biliary flow and bicarbonate output, intrinsic factor secretion, and contraction of the gallbladder.