Ansamitocin P-3 (CAS 66547-09-9) Supplier Information and Product Details

Ansamitocin P-3 is a microtubule depolymerizing agent isolated from certain Gram-positive bacteria. It binds to tubulin with a Kd of 1.3 μM, depolymerizes microtubules in both interphase and mitosis, and disrupts chromosome segregation. It also activates spindle checkpoint proteins Mad2 and BubR1, blocking cell cycling during mitosis. Ansamitocin P-3 has shown potential in inhibiting cancer cell growth in culture and suppressing tumor growth in mouse models.

Frequently Asked Questions about Ansamitocin P-3

Q: What is the primary use of Ansamitocin P-3?

A: Ansamitocin P-3 is primarily used as a microtubule inhibitor in research settings. It has shown potential as an antitumor agent due to its ability to disrupt cell division and inhibit cancer cell growth.

Q: How should Ansamitocin P-3 be stored?

A: Ansamitocin P-3 should be stored at 2-8°C. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Q: What is the mechanism of action of Ansamitocin P-3?

A: Ansamitocin P-3 acts by binding to tubulin, depolymerizing microtubules, and disrupting chromosome segregation. It also activates spindle checkpoint proteins, which leads to cell cycle arrest during mitosis.

Q: Is Ansamitocin P-3 safe to handle?

A: Ansamitocin P-3 should be handled with caution. It is classified as harmful (Xn) and carries risk statements 20/22 and 36/37/38, indicating potential harm if inhaled or swallowed, and possible irritation to eyes, respiratory system, and skin.