Combretastatin A4 Phosphate Disodium Salt (CAS 168555-66-6) Suppliers and Product Information

Combretastatin A4 phosphate disodium salt, also known as fosbretabulin disodium or CA4P, is a microtubule destabilizing drug and a water-soluble prodrug of combretastatin A4 (CA4). It functions as a tumor vascular targeting agent, disrupting blood supply to tumors and causing tumor cell death due to lack of oxygen and nutrients. This compound is a potent vascular disrupting agent (VDA) that exhibits antivascular effects on tumor vasculature, inducing rapid reduction in tumor blood flow and increasing cellular necrosis.

Frequently Asked Questions about Combretastatin A4 Phosphate Disodium Salt

Q: What is the mechanism of action of Combretastatin A4 phosphate disodium salt?

A: Combretastatin A4 phosphate disodium salt works by quickly interrupting the blood supply to tumors. It targets and breaks down the immature endothelial cells of newly formed blood vessels during tumor growth, while having no effect on the mature endothelial cells of normal tissue blood vessels. This leads to tumor death due to lack of oxygen and nutrients.

Q: How is Combretastatin A4 phosphate disodium salt different from other cancer treatments?

A: Its mechanism of action is distinct from general cytotoxic chemotherapy drugs and drugs that inhibit the formation of new blood vessels. Instead of directly attacking cancer cells or preventing new blood vessel formation, it targets existing tumor vasculature.

Q: How is Combretastatin A4 phosphate disodium salt synthesized?

A: It can be synthesized by phosphorylation of combretastatin A-4 using various strategies, including direct phosphorylation with phosphorochloridates or phosphites, or through phosphitylation followed by oxidation and deprotection steps.

Q: What are the potential applications of Combretastatin A4 phosphate disodium salt?

A: This compound has potential applications in cancer treatment, particularly in targeting tumor vasculature. It has shown promise in various preclinical studies and is being investigated for its efficacy against different types of tumors.