Febantel (CAS 58306-30-2) Suppliers and Product Information

Febantel is an anthelmintic used to treat various species of nematodes and cestodes in rodents, sheep, cattle, and horses. It was introduced in 1978 under the trade name Rintal. Febantel exhibits potent anthelmintic activity against parasites like G. kobayashii with an EC50 value of 0.03 mg/L and 100% efficacy at 0.1 mg/L after 48 hours of exposure.

Febantel is used in veterinary medicine and has shown a favorable safety profile, with its 48h LC50 value (5.47 mg/L) being significantly higher than its 48h EC50 value. However, it may interfere with hepatic metabolism and oxidative status, as indicated by variations in SOD, GST, and P450 gene expression.

Frequently Asked Questions about Febantel

Q: What is the primary use of Febantel?

A: Febantel is primarily used as an anthelmintic in veterinary medicine to treat various species of nematodes and cestodes in animals such as rodents, sheep, cattle, and horses.

Q: How effective is Febantel as an anthelmintic?

A: Febantel has shown potent anthelmintic activity, particularly against parasites like G. kobayashii. In vivo assays have demonstrated 100% efficacy at concentrations as low as 0.1 mg/L after 48 hours of exposure.

Q: Is Febantel safe for use in animals?

A: Febantel has demonstrated a favorable safety profile. Its 48h LC50 value (5.47 mg/L) is significantly higher than its effective concentration, indicating a good margin of safety. However, it may affect hepatic metabolism and oxidative status, so proper dosing and veterinary supervision are important.

Q: How should Febantel be stored?

A: Febantel should be stored sealed in a dry environment at a temperature between 2-8°C to maintain its stability and efficacy.