Sofalcone (CAS 64506-49-6) Suppliers and Product Information

Sofalcone is a synthetic antiulcer agent related to sophoradin, the active principle of the Chinese medicinal plant Sophora subprostata. It acts by strengthening the mucosal barrier through increased blood flow and stimulation of sulfated mucopolysaccharide synthesis. Sofalcone is used for the treatment of gastric ulcers and gastritis in Japan and South Korea.

Pharmacological action: Sofalcone increases gastric blood flow, expands gastric mucosal blood vessels, promotes gastric mucosal repair, and increases prostaglandin content in gastric tissue. It inhibits prostaglandin 5-hydroxyl prostaglandin dehydrogenase (PG), enhancing defense factors against ulcers of the digestive tract.

Pharmacokinetics: After oral administration, sofalcone is quickly absorbed with peak concentration reached in about one hour. The plasma half-life is approximately 1 hour, and it almost disappears from the blood after 2 hours. Main metabolites include reductive products of the chalcone skeleton's alpha and beta unsaturated bonds and oxidation products of the isoprene side chain. Within 48 hours, 6% to 8% is excreted in urine as isoprene chain oxidation products.

Frequently Asked Questions about Sofalcone

Q: What is the primary use of Sofalcone?

A: Sofalcone is primarily used for the treatment of gastric ulcers and gastritis. It is approved for use in Japan and South Korea as a gastrointestinal drug.

Q: How does Sofalcone work?

A: Sofalcone works by strengthening the mucosal barrier in the stomach. It increases gastric blood flow, expands gastric mucosal blood vessels, promotes gastric mucosal repair, and increases prostaglandin content in gastric tissue.

Q: What is the recommended storage condition for Sofalcone?

A: Sofalcone should be stored at a temperature between 2-8°C (35.6-46.4°F).

Q: Is Sofalcone soluble in water?

A: Sofalcone is slightly soluble in chloroform and ethyl acetate. Its solubility in water is not specifically mentioned in the provided information.

Q: What is the half-life of Sofalcone in the body?

A: The plasma half-life of Sofalcone is approximately 1 hour. It almost disappears from the blood after 2 hours.