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NOMIFENSINE MALEATE (CAS 24526-64-5) Suppliers and Product Information

bob
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2024-07-31 06:55:59
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Property	Value
Product Name	NOMIFENSINE MALEATE
CAS Number	24526-64-5
Molecular Formula	C16H18N2
Molecular Weight	238.33
Melting Point	179-181°C
Density	0.9597 (rough estimate)
Storage Temperature	2-8°C (protect from light)
Solubility	DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): Partially soluble

Nomifensine is an inhibitor of norepinephrine (NE) and dopamine (DA) reuptake. It inhibits uptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes with IC50 values of 6.6, 48, and 830 nM respectively. It is selective for DA/NE and 5-HT uptake inhibition over binding to dopamine D2, α1-adrenergic, 5-HT2, and muscarinic receptors.

Frequently Asked Questions

2NOMIFENSINE MALEATE (CAS 24526-64-5) Suppliers and Product Information

Q: What is the main use of Nomifensine Maleate?

A: Nomifensine Maleate was originally developed as an antidepressant. It acts as a norepinephrine-dopamine reuptake inhibitor, increasing the amount of these neurotransmitters in the synaptic cleft.

Q: Is Nomifensine Maleate still used clinically?

A: No, Nomifensine Maleate (brand name Merital) was withdrawn worldwide in 1986 due to rare but serious side effects, including hemolytic anemia, thrombocytopenia, and hepatotoxicity.

Q: What are the storage requirements for Nomifensine Maleate?

A: Nomifensine Maleate should be stored at 2-8°C and protected from light.

Company Name	Contact	Product Details
Shanghai Daken Advanced Materials Co Ltd	86 371 66670886	Purity: 99%, Package: 100g, 1KG, 5KG, 25KG
Career Henan Chemical Co	86 0371 86658258, 8613203830695	Purity: 99%, Package: 1KG
Chongqing Chemdad Co., Ltd	86 023 6139 8061, 86 86 13650506873	Purity: 98%, Package: 1kg, 2kg, 5kg, 10kg, 25kg
Alchem Pharmtech Inc.	8485655694	Purity: 97%, Package: 1g, 10g, 100g, 1kg
Dideu Industries Group Limited	86 29 89586680, 86 15129568250	Purity: 99.9%, Package: 1g, FDA GMP CEP Approved Manufacturer

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