Foscarnet Sodium (CAS 63585-09-1) Suppliers and Product Information

Foscarnet sodium is a broad-spectrum antiviral agent used primarily for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients and acyclovir-resistant herpes simplex virus (HSV) infections. It acts by inhibiting viral DNA polymerases and reverse transcriptases.

The drug is administered intravenously, typically at 60 mg/kg three times a day for initial therapy and 90-120 mg/kg daily for maintenance therapy. It has a plasma half-life of 3-6 hours and penetrates into the cerebrospinal fluid and eyes.

Frequently Asked Questions about Foscarnet Sodium

Q: What is the primary use of Foscarnet sodium?

A: Foscarnet sodium is primarily used for treating cytomegalovirus (CMV) retinitis in AIDS patients and acyclovir-resistant herpes simplex virus (HSV) infections.

Q: How does Foscarnet sodium work?

A: Foscarnet sodium inhibits viral DNA polymerases and reverse transcriptases, preventing viral replication. It does not require activation by viral enzymes, making it effective against resistant viral strains.

Q: What are the common side effects of Foscarnet sodium?

A: Common side effects include electrolyte imbalances (such as hypocalcemia and hypokalemia), nephrotoxicity, anemia, nausea, vomiting, and in some cases, neurological symptoms like seizures.

Q: How is Foscarnet sodium administered?

A: Foscarnet sodium is administered intravenously, typically at 60 mg/kg three times a day for initial therapy and 90-120 mg/kg daily for maintenance therapy.

Q: Can Foscarnet sodium be used in combination with other antiviral drugs?

A: Yes, Foscarnet sodium can be used in combination with other antivirals. For example, it has shown promising results when used with ganciclovir for CMV retinitis, and it acts synergistically with zidovudine against HIV.