Fluphenazine Hydrochloride (CAS 146-56-5) Suppliers and Product Information

Fluphenazine hydrochloride is a potent antipsychotic phenothiazine used as a tranquilizer. It is a member of the piperazine subgroup with a trifluoromethyl group at the 2-position of the phenothiazine system. It acts as a dopamine D1 and D2 receptor antagonist and has antiandrogen and antineoplastic properties. The compound is also known by trade names such as Permitil and Prolixin.

Frequently Asked Questions about Fluphenazine Hydrochloride

Q: What is the main use of Fluphenazine Hydrochloride?

A: Fluphenazine Hydrochloride is primarily used as an antipsychotic medication. It is effective in treating various psychotic disorders and is known for its potency on a milligram basis among phenothiazine antipsychotics.

Q: Are there any special formulations of Fluphenazine Hydrochloride?

A: Yes, Fluphenazine Hydrochloride is available in long-acting depot formulations, including the enanthate (heptanoic acid ester) and decanoate ester. These are used for intramuscular injection in patients who have difficulty adhering to oral medication regimens or are prone to frequent relapses.

Q: What are the main mechanisms of action for Fluphenazine Hydrochloride?

A: Fluphenazine Hydrochloride primarily acts as a dopamine D1 and D2 receptor antagonist. It also has activity as an H1 histamine receptor antagonist. These mechanisms contribute to its antipsychotic effects.

Q: Are there any notable side effects or precautions associated with Fluphenazine Hydrochloride?

A: Like other antipsychotics, Fluphenazine Hydrochloride can cause various side effects. It may induce extrapyramidal symptoms, and long-term use can lead to tardive dyskinesia. The compound is also hygroscopic and sensitive to light, requiring proper storage conditions. Always consult a healthcare professional for medical advice and proper usage instructions.