Property | Value |
---|---|
Product Name | Betahistine |
CAS Number | 5638-76-6 |
Molecular Formula | C8H12N2 |
Molecular Weight | 136.19 |
Boiling Point | 113-114 °C (30 mm Hg) |
Density | 0.984 g/mL at 25 °C |
Vapor Pressure | 17.7 Pa at 25°C |
Flash Point | 206 °F |
Water Solubility | 1000 g/L at 25°C |
LogP | 0.68 |
Betahistine is a histamine ***og with weak agonist properties at histamine H1 receptors and more potent antagonistic effects at histamine H3 receptors. It is used to treat vertigo, tinnitus, and hearing loss associated with Ménière's disease. The drug acts as a vasodilator and is thought to improve microcirculation in the inner ear.
Q: What is the mechanism of action of betahistine?
A: Betahistine acts as a weak partial agonist at histamine H1 receptors and a more potent antagonist at H3 receptors. It is believed to improve blood flow in the inner ear and brainstem, potentially reducing endolymphatic pressure. The drug may also inhibit activity in the vestibular nuclei.
Q: What are the common side effects of betahistine?
A: Common adverse reactions include headache, nausea, and dyspepsia. Less frequently, hypersensitivity reactions such as rash, pruritus, bronchospasm, and hypotension may occur.
Q: How is betahistine typically administered?
A: Betahistine is usually provided as 16 mg scored tablets. The typical dose is 8-16 mg taken three times daily with food to minimize gastrointestinal upset. Patients should be advised that it may take several weeks to notice beneficial effects.
Company Name | Tel | Products Intro |
---|---|---|
Hangzhou Benoy Chemical Co., Ltd | 8617342059697 | Betahistine, CAS 5638-76-6, Purity ≥98%, Package: 5KG/1KG/500g/100g |
Henan Tianfu Chemical Co., Ltd. | 86-0371-55170693, 86-19937530512 | Betahistine, CAS 5638-76-6, Purity ≥99%, Package: 25KG/5KG/1KG |
ATK CHEMICAL COMPANY LIMITED | 86-21-51877795 | Betahistine, CAS 5638-76-6, Purity ≥98%, Package: 5MG/10MG/50MG/100MG/1G/5G |
Hubei Jusheng Technology Co., Ltd. | 18871490254 | Betahistine, CAS 5638-76-6, Purity ≥99%, Package: 5KG/1KG, Remarks: C8H12N2 |
BOC Sciences | 1-631-485-4226 | Betahistine, CAS 5638-76-6, Purity ≥98%, Package: 2g, Custom synthesis available |
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