2-Phenyl-1,3-indandione (CAS 83-12-5) Suppliers and Product Information

2-Phenyl-1,3-indandione, also known as phenindione, is an anticoagulant and vitamin K antagonist. It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates. The compound is used for preventing and treating thrombosis, thrombophlebitis, and thromboembolism.

Frequently Asked Questions

Q: What is the main use of 2-Phenyl-1,3-indandione?

A: 2-Phenyl-1,3-indandione, also known as phenindione, is primarily used as an oral anticoagulant. It acts by altering the biosynthesis of coagulant proteins in the liver and is used for preventing and treating thrombosis, thrombophlebitis, and thromboembolism.

Q: Are there any side effects associated with 2-Phenyl-1,3-indandione?

A: Yes, 2-Phenyl-1,3-indandione can cause several side effects, including polyuria, polydipsia, and tachycardia. Due to these side effects, it is rarely used in practical medicine compared to other anticoagulants.

Q: How does 2-Phenyl-1,3-indandione interact with other drugs?

A: 2-Phenyl-1,3-indandione has many significant interactions with other drugs. Its anticoagulant effect can be enhanced by various substances including alcohol, certain antibiotics, and NSAIDs. Conversely, its effect can be decreased by oral contraceptives and rifamycins. It's important to prescribe this drug with care and consider potential interactions.