PENTOSTATIN (CAS 53910-25-1) Supplier Information and Product Details

PENTOSTATIN is a potent antitumor antibiotic isolated from Streptomyces species. It is a purine nucleoside ***og that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM), interrupting DNA synthesis in dividing cells. The drug is primarily used in the treatment of hairy cell leukemia and has shown efficacy in treating relapsed chronic lymphocytic leukemia.

Frequently Asked Questions about PENTOSTATIN

Q: What is the primary use of PENTOSTATIN?

A: PENTOSTATIN is primarily used for the treatment of hairy cell leukemia. It has also shown efficacy in treating other types of leukemia, such as chronic lymphocytic leukemia.

Q: How does PENTOSTATIN work?

A: PENTOSTATIN works by inhibiting the enzyme adenosine deaminase, which leads to an accumulation of deoxyadenosine triphosphate (dATP) in cells. This accumulation is toxic to lymphocytes, particularly cancerous ones, thereby interrupting DNA synthesis and cell division.

Q: What are the main side effects of PENTOSTATIN?

A: The major toxic effects of PENTOSTATIN include myelosuppression, nausea, skin rashes, immunosuppression, headache, lethargy, and fatigue. Fatal pulmonary toxicity has been reported when used in combination with fludarabine.

Q: How is PENTOSTATIN administered?

A: PENTOSTATIN is administered intravenously (IV) due to its acid instability, which prevents oral administration. It is typically available in 10 mg vials for IV use.