Galanthaminone (CAS 510-77-0): Suppliers and Product Information

Galanthaminone, also known as Narwedine, is a metabolite of Galanthamine and a competitive, reversible cholinesterase (AChE) inhibitor. It is used in the treatment of mild to moderate Alzheimer's disease and has been studied as a respiratory stimulator. Galanthaminone increases the amplitude and decreases the frequency of cardiac contractions, potentially valuable in reducing blood loss during surgery. It also inhibits the action of ***s and hypnotics while increasing the ***gesic effect of *** and the pharmacological effects of caffeine, carbazole, arecoline, and nicotine.

Frequently Asked Questions about Galanthaminone

Q: What is the primary use of Galanthaminone?

A: Galanthaminone is primarily used in the treatment of mild to moderate Alzheimer's disease. It is also studied for its potential as a respiratory stimulator and for its effects on cardiac function.

Q: How does Galanthaminone work?

A: Galanthaminone acts as a competitive and reversible cholinesterase (AChE) inhibitor. This mechanism is believed to be responsible for its therapeutic effects in Alzheimer's disease.

Q: What are the solubility properties of Galanthaminone?

A: Galanthaminone is soluble in DMSO up to 10 mg/mL (35.05 mM), but it is practically insoluble in water (≤0.1 mg/mL).

Q: How should Galanthaminone be stored?

A: Galanthaminone should be stored sealed in a dry environment at a temperature between 2-8°C.