Product Name | CAS Number | Molecular Formula | Molecular Weight | EINECS |
---|---|---|---|---|
Amorolfine | 67467-83-8 | C21H35NO | 317.51 | 1312995-18-2 |
**Chemical Properties:** - Boiling point: 407.1±33.0 °C (Predicted) - Density: 0.924±0.06 g/cm3 (Predicted) - Storage temperature: Refrigerator, under inert atmosphere - Solubility: Slightly soluble in Chloroform and Methanol - Form: Oil - pKa: 7.33±0.10 (Predicted) - Color: Colorless
**Uses:** Amorolfine is an antifungal agent used in the treatment of cutaneous fungal diseases. It is available for topical use in 0.25% cream and 5% nail lacquer formulations, primarily for the treatment of onychomycosis in European countries and Japan. The drug is not approved in the USA for these indications.
**Side Effects:** Topical application of amorolfine (5% nail lacquer and 0.25% cream) is generally well tolerated. Up to 5% of patients may report minor symptoms such as burning, itching, redness, and local pain at the application site. Adverse effects like scaling, weeping, blistering, and edema have also been reported for the cream formulation.
**Q: What is the mechanism of action of Amorolfine?** A: Amorolfine works by inhibiting the enzyme sterol 14α-demethylase, which is crucial for ergosterol biosynthesis in fungal cell membranes. This disruption in ergosterol production leads to the accumulation of toxic sterol precursors, ultimately causing fungal cell death.
**Q: What are the common formulations of Amorolfine?** A: Amorolfine is commonly available as a 5% nail lacquer and a 0.25% cream for topical application. The nail lacquer is primarily used for treating fungal nail infections (onychomycosis).
**Q: Is Amorolfine approved for use in the United States?** A: No, Amorolfine is not currently approved by the FDA for use in the United States. It is, however, available in many European countries and Japan for the treatment of fungal infections.
**Q: What types of fungal infections can Amorolfine treat?** A: Amorolfine is effective against various fungal infections, particularly those caused by dermatophytes and Candida species. It is most commonly used to treat onychomycosis (fungal nail infections) and some superficial skin infections.
Company Name | Contact | Product Details |
---|---|---|
Beijing Cooperate Pharmaceutical Co Ltd | 010-60279497 | Amorolfine hydrochloride, Purity: 98-99%, Package: 100G-100KG |
Henan Tianfu Chemical Co Ltd | 86 0371 55170693, 86 19937530512 | Amorolfine, Purity: 99%, Package: 25KG, 5KG, 1KG |
Hubei XinRunde Chemical Co., Ltd | 8615102730682 | Amorolfin, Purity: 99%, Package: 100g-25kg or as required |
Career Henan Chemical Co | 86 0371 86658258, 8613203830695 | Amorolfine, Purity: 99%, Package: 1kg |
Hubei Jusheng Technology Co Ltd | 18871490254 | cis-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine, Purity: 99%, Package: 5KG, 1KG |
This article was written by bob and published on 2024-08-04 16:28:57. Original article, reproduction is prohibited. The content is for entertainment purposes only and should not be taken as fact.
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