Wortmannin (CAS 19545-26-7) Suppliers and Product Information

Wortmannin is a potent, selective, cell-permeable, and irreversible inhibitor of phosphatidylinositol 3-kinase (PI3K) with an IC50 of 2-5 nM. It also inhibits polo-like kinase 1 (PLK1) with an IC50 of 5.8 nM. Wortmannin is widely used in research as a tool for probing PI3K-mediated cellular events and has applications in studying autophagy, cell signaling, and cancer biology.

Frequently Asked Questions about Wortmannin

Q: What is the primary use of Wortmannin in research?

A: Wortmannin is primarily used as a potent inhibitor of phosphatidylinositol 3-kinase (PI3K). It is widely employed in cell biology research to study PI3K-mediated cellular events, inhibit DNA repair, receptor-mediated endocytosis, and cell proliferation.

Q: How stable is Wortmannin?

A: Wortmannin is stable for 1 year from the date of purchase when supplied and stored properly. Dried aliquots evaporated from ethanol may be stored at -20°C for several months. However, solutions are not stable and must be used within one working day.

Q: What are some precautions when handling Wortmannin?

A: Wortmannin is light-sensitive and should be protected from light. It is also classified as toxic and should be handled with care. Appropriate personal protective equipment should be used, and safety guidelines should be followed when working with this compound.