Prenylamine (CAS 390-64-7) Suppliers and Product Information

Prenylamine is a calcium channel inhibitor used in biochemical research. It inhibits the plasma membrane Ca2 ATPase (PMCA) in isolated and purified pig cardiac sarcolemma. Prenylamine binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 μM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity at concentrations ranging from 10 to 50 μM. It has been used in studies related to cardiac function and neurotransmitter levels in the brain.

Frequently Asked Questions about Prenylamine

Q: What is the primary use of prenylamine?

A: Prenylamine was primarily used as a vasodilator for the prophylaxis of angina pectoris and long-term treatment of coronary heart disease. However, it has been withdrawn from the market due to concerns about its potential to induce dangerous cardiac dysrhythmias.

Q: What are the effects of prenylamine on cardiac function?

A: Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes. At lower doses (0.5 mg/kg), it can protect anesthetized rats from coronary artery occlusion-induced arrhythmia. However, at higher doses (5 mg/kg), it increases mortality due to atrioventricular block leading to asystole.

Q: How does prenylamine affect neurotransmitter levels?

A: Prenylamine (50 mg/kg) has been shown to decrease epinephrine, serotonin, and dopamine levels in rat brain. It also decreases epinephrine levels in rat heart.