Cloprostenol Sodium Salt (CAS 55028-72-3) Suppliers and Product Information

Cloprostenol sodium salt is a water-soluble prostaglandin F2α (PGF2α) ***og that acts as a potent FP receptor agonist with an EC50 of 0.84 nM. It is used as a veterinary drug, particularly in cattle, for inducing luteolysis and managing various reproductive conditions. The compound is available as an aqueous solution containing 250 mg/mL under the brand name Estrumate (Bayer AnimalHealth).

Uses include: - Inducing luteolysis in cattle - Managing unobserved or undetected estrus in normally cycling cows - Treating pyometra or chronic endometritis - Expelling mummified fetuses - Treating luteal cysts - Inducing abortions after mismating - Scheduling estrus and ovulation for controlled breeding

In research settings, cloprostenol sodium salt has been shown to potently inhibit the differentiation of adipocyte precursor cells.

Frequently Asked Questions

Q: What is the recommended dosage for cloprostenol sodium salt in cattle?

A: The recommended dosage is not provided in the given information. It's important to consult a veterinarian or the product label for specific dosing instructions, as it may vary depending on the intended use and the animal's condition.

Q: Are there any side effects associated with cloprostenol sodium salt use?

A: Yes, some potential side effects have been reported: - Low incidence of clostridial and other infections at the injection site - Rarely, anaphylactic reactions - At 50-100 times the recommended dose: increased uneasiness, mild transient diarrhea, slight frothing, and milk letdown It's crucial to monitor treated animals closely and initiate appropriate antibiotic therapy if signs of infection appear.

Q: Can cloprostenol sodium salt be used in animals other than cattle?

A: While primarily approved for use in beef and dairy cattle, cloprostenol has been used in dogs for pregnancy termination and treatment of open pyometra. However, its use in dogs is controversial, as some believe dinoprost (PGF2alpha) may be more effective and have fewer adverse effects for pyometra treatment in dogs.