Product Name | CAS Number | Molecular Formula | Molecular Weight | Melting Point | Purity |
---|---|---|---|---|---|
Ibandronic Acid | 114084-78-5 | C9H23NO7P2 | 319.23 | 113-115°C | ≥99% |
Ibandronic Acid is a third-generation bisphosphonate used for the treatment of bone disorders such as hypercalcemia in malignancy, osteodysis, Paget's disease, and osteoporosis. It acts as a bone resorption inhibitor by interacting with hydroxyapatite crystals and inhibiting osteoclast-mediated bone resorption.
Chemical Properties: - Appearance: White solid - Solubility: Slightly soluble in aqueous base, methanol, and water - Storage: Store in freezer under -20°C, sealed in dry conditions - Stability: Hygroscopic
Uses: - Treatment of bone disorders - Reduction of bone damage in bone metastases in breast cancer - Treatment of hypercalcaemia of malignancy - Management of postmenopausal osteoporosis
Q: What is the mechanism of action of Ibandronic Acid?
A: Ibandronic Acid is a bisphosphonate that inhibits osteoclast-mediated bone resorption. While the exact mode of action is not fully understood, it strongly interacts with hydroxyapatite crystals in the bone, leading to a reduction in bone turnover and increased bone density.
Q: How is Ibandronic Acid metabolized in the body?
A: Ibandronic Acid is not metabolized in animals or humans. After initial systemic exposure, it rapidly binds to bone or is excreted into urine. Approximately 40-50% of the absorbed fraction is removed from circulation via bone absorption in postmenopausal women, while the remainder is eliminated unchanged by the kidney. The unabsorbed fraction is eliminated unchanged in the feces.
Q: What are the advantages of Ibandronic Acid over first-generation bisphosphonates?
A: Ibandronic Acid, as a third-generation bisphosphonate, does not affect bone mineralization. This prevents the potential risk of osteomalacia, which was a problem with first-generation derivatives. It is also well-tolerated and considered safe for long-term use.
Company Name | Contact | Product Details |
---|---|---|
Henan Tianfu Chemical Co., Ltd. | 86 0371 55170693 86 19937530512 | Purity: 99% Package: 25KG, 5KG, 1KG |
Career Henan Chemical Co. | 86 0371 86658258 86 13203830695 | Purity: 99% Package: 1kg (7USD) |
Xiamen AmoyChem Co., Ltd. | 86 592 6051114 86 18959220845 | CAS: 114084-78-5 |
Chongqing Chemdad Co., Ltd. | 86 023 6139 8061 86 13650506873 | Purity: 98% Package: 1kg, 2kg, 5kg, 10kg, 25kg |
CONIER CHEM AND PHARMA LIMITED | 86 18523575427 | Purity: 99% Package: 1kg |
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